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Fig. 4 | Mycobacteria

Fig. 4

From: C3HeB/FeJ mice with chronic Mycobacterium avium complex pulmonary infection exhibit impaired respiratory function but not necrotising granulomatous disease

Fig. 4

Whole body plethysmography in C3HeB/FeJ mice infected with MAC104. Mice infected with high-dose inoculum MAC104 exhibited evidence of increasing respiratory effort over 12 weeks’, evidence by significantly higher respiratory rate (A), tidal volume (B), inspiratory flow rate (C) and expiratory flow rate (D) (p < 0.0001). These mice also had significantly reduced inspiration time (E), end-inspiratory pause (F), expiration time (G) and end-expiratory pause (H) (p < 0.0001). Mice with low dose infection had similar respiratory response, but less pronounced. Data points displayed as 3-point moving mean for time-course graphs (with error bars removed for clarity). Data displayed mean + SD for AUC graphs and analysed by one-way ANOVA with Turkey’s multiple comparison test. Data representative of one study with n = 4 per group. ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant; Un, uninfected; LDI, low dose inoculum; HDI, high dose inoculum

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Mycobacteria

ISSN: 3004-9555

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