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Fig. 2 | Mycobacteria

Fig. 2

From: C3HeB/FeJ mice with chronic Mycobacterium avium complex pulmonary infection exhibit impaired respiratory function but not necrotising granulomatous disease

Fig. 2

Whole body plethysmography in C3HeB/FeJ mice infected with MAC2285R. Mice infected with high-dose inoculum MAC2285R exhibited evidence of increasing respiratory effort over 12 weeks’, evidence by significantly higher respiratory rate (A), tidal volume (B), inspiratory flow rate (C) and expiratory flow rate (D) (p < 0.0001 for all). Mice with low dose infection did not exhibit any significant differences in these parameters compared to uninfected mice. MAC infection led to reduced inspiration time (E) and end-inspiratory pause (F), regardless of infectious dose, but only high dose infection was associated with reduced expiration time (G) and end-expiratory pause (H) (p < 0.0001). Data points displayed as 3-point moving mean for time-course graphs (with error bars removed for clarity). Data displayed mean + SD for AUC graphs and analysed by one-way ANOVA with Turkey’s multiple comparison test. Data representative of one study with n = 4 per group. **** p < 0.0001; ns, not significant; Un, uninfected; LDI, low dose inoculum; HDI, high dose inoculum

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Mycobacteria

ISSN: 3004-9555

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